The purpose of this study is to investigate the link between the lungs and rheumatoid
arthritis (RA). Additionally, to understand why RA patients get lung disease, how to
treat, and prevent the disease.

Investigate the Development and Progression of Lung Disease in Rheumatoid Arthritis Over Time

Rheumatoid Arthritis

Lung Diseases

This study is to learn more about the risk factors for the development of lung disease
among patients with rheumatoid arthritis (RA), an auto-immune disease. Additionally,
those at heightened risk of developing RA such as in the pre-RA period. This is a
prospective and retrospective study, which 420 patients will be enrolled into the study.
In-person participation will be up to 4 years, completing different standard of care
assessments yearly. Additionally, quality of life questionnaires will be completed every
6 months at 4 time points. Lastly, an extended follow-up will be performed yearly for an
additional 6 years, an overall 10 year participation.

Change in Serum and Sputum Biomarkers Over Time in the Development of Rheumatoid Arthritis-associated Lung Disease

Subjects with interstitial lung disease (ILD) or airways disease, no rheumatoid arthritis
(RA), and positive antibodies will participate in 5 in-person study visits. Additionally,
quality of life questionnaires will be mailed/emailed and completed at home every 6
months, at 4 different time points. Overall participation will take place over a 4 year
time frame and an additional 6 years of survival follow-up.

In-person Study Assessments Include:

  1. Medical History and Physical Exams

  2. Quality of Life Questionnaires

  3. Collection of blood

  4. Radiology

  5. Lung Function Test

  6. 6 Minute Walk Test

  7. Bronchoscopy (Clinically indicated)

  8. Sputum (Optional)

  9. Musculoskeletal ultrasound (Optional)

Subjects with rheumatoid arthritis (RA), and no interstitial lung disease (ILD) or
airways disease, will participate in 5 in-person study visits. Additionally, quality of
life questionnaires will be mailed/emailed and completed at home every 6 months, at 4
different time points. Overall participation will take place over a 4 year time frame and
an additional 6 years of survival follow-up.

In-person Study Assessments Include:

  1. Medical History and Physical Exams

  2. Quality of Life Questionnaires

  3. Collection of blood

  4. Radiology

  5. Lung Function Test

  6. 6 Minute Walk Test

  7. Bronchoscopy (Clinically indicated)

  8. Sputum (Optional)

  9. Musculoskeletal ultrasound (Optional)

Subjects with rheumatoid arthritis (RA) and interstitial lung disease (ILD) or airways
disease, will participate in 5 in-person study visits. Additionally, quality of life
questionnaires will be mailed/emailed and completed at home every 6 months, at 4
different time points. Overall participation will take place over a 4 year time frame and
an additional 6 years of survival follow-up.

In-person Study Assessments Include:

  1. Medical History and Physical Exams

  2. Quality of Life Questionnaires

  3. Collection of blood

  4. Radiology

  5. Lung Function Test

  6. 6 Minute Walk Test

  7. Bronchoscopy (Clinically indicated)

  8. Sputum (Optional)

  9. Musculoskeletal ultrasound (Optional)

Subjects with interstitial lung disease (ILD) or airways disease, no rheumatoid arthritis
(RA), and negative antibodies will participate in 5 in-person study visits. Additionally,
quality of life questionnaires will be mailed/emailed and completed at home every 6
months, at 4 different time points. Overall participation will take place over a 4 year
time frame and an additional 6 years of survival follow-up.

In-person Study Assessments Include:

  1. Medical History and Physical Exams

  2. Quality of Life Questionnaires

  3. Collection of blood

  4. Radiology

  5. Lung Function Test

  6. 6 Minute Walk Test

  7. Bronchoscopy (Clinically indicated)

  8. Sputum (Optional)

  9. Musculoskeletal ultrasound (Optional)

Investigate the Development and Progression of Lung Disease in Rheumatoid Arthritis Over Time

About this trial

Study ID

Status

Type

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status