this study will be undertaken-to evaluate the effect of oral amantadine versus IV
amantadine premedication on the hemodynamic response to laryngoscopy ,tracheal intubation
and surgical incision and their effect on β-endorphins.

Oral Amantadine, IV Amantadine and Hemodynamic Response to Laryngoscopy

Intubation, Intratracheal

Direct laryngoscopy and passage of endotracheal tube through the larynx is a noxious
stimulus, which can provoke untoward response in the cardiovascular, respiratory and
other physiological systems .Amantadine is a non-competitive NMDA receptor antagonist,
and compared to ketamine, it is well tolerated with fewer side effects (mainly dizziness,
sedation, and dry mouth). Amantadine's formulation permits the oral route for drug
delivery, as well as the IV route. The side-effects profile of amantadine via all routes
seems not to be harmful in appropriate dosages.. Amantadine has been clinically used as
an antiviral drug, for dementia, and in the treatment of Parkinson's disease and
spasticity. It is a non-competitive NMDA receptor antagonist, and compared to ketamine,
it is well tolerated with fewer side effects (mainly dizziness, sedation, and dry mouth).
Amantadine's formulation permits the oral route for drug delivery, as well as the IV
route. The side-effects profile of amantadine via all routes seems not to be harmful in
appropriate dosages.

In the central nervous system, beta-endorphins bind mu-opioid receptors and exert their
primary action at presynaptic nerve terminals. However, instead of inhibiting substance
P, they exert their analgesic effect by inhibiting the release of GABA, an inhibitory
neurotransmitter, resulting in excess production of dopamine.

this study will be undertaken-to evaluate the effect of oral amantadine versus IV
amantadine premedication on the hemodynamic response to laryngoscopy ,tracheal intubation
and surgical incision and their effect on β-endorphins.

oral Amantadine sulfate

i.v Amantadine Sulfate

placebo tablet

Oral Amantadine Versus IV Amantadine to Attenuate the Hemodynamic Response to Laryngoscopy, Tracheal Intubation and Surgical Incision and Their Effect on β-endorphin: A Randomized Clinical Trial

changes of the mean arterial blood pressure (mmhg)

Principal Investigator

the patients will receive oral amantadine sulfate using the dose 100 mg 90 minute prior
to the surgery and infusion of100cm I.V saline

the patients will receive 100 mg I.V amantadine sulfate infusion over 60minute prior to
the surgery and placebo tablet 90 minute prior to the surgery

the patients will receive placebo tablet 90 minute prior to the surgery and infusion of
100cm I.V saline over 60minute prior to the surgery

Oral Amantadine, IV Amantadine and Hemodynamic Response to Laryngoscopy

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Not accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status