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Pulsed Electro Magnetic Fields (PEMF) in Depression

Sponsored by University of Southern Denmark

About this trial

Last updated 7 years ago

Study ID

1-10-72-125-16

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18 to 80 Years
All Sexes

Trial Timing

Ended 8 years ago

What is this trial about?

PEMF (Pulsed Electro Magnetic Fields) therapy has been used to stimulate bone repair in non-union since the 1970s. This is an accepted use, which has been approved by the Food and Drug Administration in the US. The mode of action of PEMF is based on creating small electrical fields in tissue and thereby promoting healing. Besides it has been shown that PEMF enhance regeneration of nerve fibers exposed to a lesion For treatment of depression the PEMF equipment, which are provided by the company Re5 A/S, consists of a 220 V impulse generator that creates electrical impulses and an applicator which consists of an electrical cable connected to a helmet on which there are 7 electrical coils on the inside. In comparison with the rTMS (Transcranial Magnetic Stimulation) equipment, which uses stimuli approaching neuronal firing level, the PEMF fields in human is very much lower.

What are the participation requirements?

Inclusion Criteria

* Treatment resistant depression is defined as treatment with at least two antidepressants from different classes in an optimal dose and with sufficient duration (at least 8 weeks). * A score on HamD17 above 17. * Antidepressant medication must not have been changed 4 weeks before inclusion.

Exclusion Criteria

A Ham-D17 item 3 at 2 or more (suicidal risk increased) A moderate manic condition (MAS-M above 14) The participant must not be under some sort of restrictions Pregnancy Severe personality disorders Psychotic mental disorders Brain diseases