Effect of THRIVE During Apneic Oxygenation in General Anesthesia on Biomarkers
Sponsored by Karolinska University Hospital
About this trial
Last updated 6 years ago
Study ID
Bio-THRIVE
Status
Completed
Type
Interventional
Phase
N/A
Placebo
No
Accepting
18+ Years
All Sexes
Trial Timing
Ended 8 years ago
What is this trial about?
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as biological stress response detected by blood-bourne biomarkers before implementing it into clinical practice.
What are the participation requirements?
Inclusion Criteria
1. Adults, >18 years old.
2. Laryngeal-surgery where apnea is of benefit for the surgeon (eg. intraoral or laryngeal surgery).
3. Capable of understanding the study information and sign the written consent.
Exclusion Criteria
1. American Society of Anaesthesiologist severity score >2
2. New York Heart Association score >2
3. Pacemaker or ICD.
4. Body Mass Index >35
5. Pregnancy
6. Manifest cardiac failure or coronary disease
7. Severe gastrointestinal reflux.
8. Neuromuscular disorder