Three-Chamber Bags Retrospective Study in Spain

1. Adult hospital inpatients ≥ 18 years

2. Treatment with PN for at least 3 consecutive days

3. PN containing all three major macronutrients, delivered from 3CB or HCB

4. Patients with hospital admission between January 1, 2013, and December 31, 2015 (study period)

1. Bloodstream infection before or at the same day of first PN administration

2. Immunosuppression due to concomitant therapy (e.g., immunosuppressive therapy due to transplantation, concomitant oral or intravenous administration of glucocorticoids) or disease (e.g., HIV, leukaemia)

3. Permanent vascular access (port, shunts for dialysis)

4. Femoral venous placement of central venous line used for PN

5. Burns, extensive skin injuries (e.g., Lyell´s disease)

6. Chemo-/radiotherapy for up to 3 months before hospital admission

7. Change of PN bag type during observation period, e.g., from HCBs to 3CBs or vice-versa