To evaluate the efficacy of Moxibustion in the treatment of Ulcerative Colitis, thus the
      scientific foundation for rational use of Moxibustion in clinical usage, in order to find
      admission of the Acupuncture and Moxibustion and even medicine field, accomplish
      popularization and application.

The Promotion Plan of Moxibustion on Ulcerate Colitis

Ulcerative Colitis

A total of 128 patients with UC were randomly divided into the following 2 groups: a)
      Herb-partition moxibustion (Treatment Group) and b) Sham herb-partition moxibustion (Control
      Group). All patients in the trial will be treated with moxibustion 3 times a week, once a day
      for 30 minutes, for a total of 12 weeks. After treating the treatment had ended and the 52nd
      week of follow-up to observe the clinical therapy effect of Moxibustion in UC patients.
      Tissue morphology and molecular biology tests will be conducted to observe the regulation in
      the intestinal mucosa of UC patients. All these steps will be done in order to provide
      clinical usage for the effects of herb-partition moxibustion in the treatment of UC.

Herb-partitioned moxibustion

Sham herb-partitioned moxibustion

A Study on the Promotion Plan of the Moxibustion Treatment of Ulcerate Colitis

The curative effect of Herb-partitioned moxibustion for 128 UC patients.

Assay for the ulcerative colitis desease activity index. It is constructed by four scales, Including stool frequency、rectal bleeding、mucosal appearance at endoscopy and physician rating of disease activity. Every scale can be scored with o ,1 ,2 or 3 according to the activity index of scale. Scores should be compared to previous scores taken for a patient. The higher the score (minimum 0 point and maximum 12 points), the more severe the ulcerative colitis.

Observe the abdominal pain, bloody stool, intolerance of cold, soreness and weakness of waist an knees, diarrhea, mucous stool, tenesmus, anorexia and lassitude score.

Life quality was determined by the total score of the 32 questions. Each question is given 1-7 different degrees of answer. One represents the heaviest degree and seven represents the lightest degree. The lower the score (minimum 32 points and maximum 224 points), the worse the life quality.

The HADS is a fourteen item scale that generates ordinal data. Seven of the items relate to anxiety and seven relate to depression. Each item on the questionnaire is scored from 0-3 .The higher the total score (minimum 0 point and maximum 21 points), the more severe the anxiety or depression.

Assay for the quantification of total C-reaction protein in serum.(Normal reference value:<10mg/L)

Assay for the quantification of total Erythrocyte sedimentation rate in serum.(Normal reference value: male 0～15mm/h; female 0～20mm/h)

evaluate the gut mucosal state by using electronic colonoscopy

Observe the intestinal mucosal tissue changes by HE staining

Drug: Herbal cake, Device: Moxibustion. Herbal cakes formula: Monkshood 10g, Cinnamon 2g, Salvia miltiorrhiza 3g, Flos Carthami 3g, Radix Aucklandiae 2g. Herbs are smashed into powder. Every 2.5g medicine powder is mixed with 3g millet wine and then pressed into herbal cakes using a specific mold. Each cake should be 23mm in diameter and 5mm in height. Then, ignited moxa cones are placed on top of each herbal cake. Herbal cakes with moxa cones will be positioned at acupuncture points ST25, ST37 and CV6. The entire treatment will be done once a day for 1 moxa cone every acupuncture point, 30 minutes at a time, 3 times a week, for a total of 12 weeks.

Drug: Herbal cake, Device: Sham moxibustion. Herbal cakes formula: Monkshood 10g, Cinnamon 2g, Salvia miltiorrhiza 3g, Flos Carthami 3g, Radix Aucklandiae 2g. Herbs are smashed into powder. Every 2.5g medicine powder is mixed with 3g millet wine and then pressed into herbal cakes using a specific mold. Each cake should be 23mm in diameter and 5mm in height. Then, ignited moxa cones are placed on top of each herbal cake. Small cardboard sheets with the same size as the herbal cakes will be wrapped with aluminum foil and placed under each herbal cake. These herbal cakes will be positioned at acupuncture points ST25, ST37 and CV6. The entire treatment will be done once a day for 1 moxa cone every acupuncture point, 30 minutes at a time, 3 times a week, for a total of 12 weeks.

The Promotion Plan of Moxibustion on Ulcerate Colitis

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?