Sepsis
+1
The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
Sponsored by Susan Smyth
About this trial
Last updated 5 years ago
Study ID
16-0784-F6A
Status
Withdrawn
Type
Interventional
Phase
N/A
Placebo
No
Accepting
18+ Years
All Sexes
Trial Timing
Ended 5 years ago
What is this trial about?
Sepsis is life-threatening and dysregulated response to infection that results in endothelial activation and dysfunction that leads to systemic microvascular leak and multiple-organ failure. This study will identify patients that have sepsis with thrombocytopenia and randomize them to receive a unit of platelets or an equivalent volume of saline.
What are the participation requirements?
Inclusion Criteria
* Provision of informed consent prior to any study specific procedures
* Female and/or male, age >18 years
* Diagnosis of sepsis based on the Third International Consensus Definitions for Sepsis and Septic Shock
* Platelet count ≤ 50,000/μL
Exclusion Criteria
* Active major bleeding requiring blood transfusion
* Other causes of thrombocytopenia such as idiopathic thrombocytopenic purpura, high clinical suspicion for heparin-induced thrombocytopenia (or other form of consumptive coagulopathy).