Circumcision Versus Preputioplasty for BXO in Children
Sponsored by Alder Hey Children's NHS Foundation Trust
About this trial
Last updated 7 years ago
Study ID
BXO
Status
Completed
Type
Interventional
Phase
N/A
Placebo
No
Accepting
2 to 16 Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended 7 years ago
What is this trial about?
Traditionally, BXO is managed with circumcision (surgical removal of the foreskin) and this
approach has long been held as the 'gold standard. Whilst this may be curative in many cases,
it has been shown that 20% of boys require a further operative procedure on their penis to
widen the urethral opening (to treat meatal stenosis)
An alternative to circumcision was proposed: a preputioplasty (surgery to widen the opening
of the foreskin) was combined with injection of steroids into the affected foreskin.
Subsequently, the same group compared the outcomes of this technique with circumcision, and
reported circumcision was successfully avoided in 92% of the preputioplasty group. In
addition, the rate of meatal stenosis (narrowing of the urethral opening requiring surgery)
was significantly lower (6% vs 19%, P = .034 ). Preputioplasty may therefore: (i) offer
protection against meatal stenosis and reduce the requirement for further surgery; and (ii)
offer the benefit of retaining the foreskin, the function of which, while debated, likely
includes sexual function. In view of these potential benefits, authors have called for a
randomised trial to compare circumcision to preputioplasty and injection of steroids.
What are the participation requirements?
Inclusion Criteria
- aged between 2 and 16 years
- diagnosed with BXO
- require surgery to treat BXO
Exclusion Criteria
- previous penile surgery
- circumcision or preputioplasty medically contraindicated