Lymphatic filariasis is a public health problem in Mali. The existing data are not up to
date and most of them are more than 15 years old. To address this issue in April 2000,
the investigators started studies to update the epidemiology of lymphatic filariasis.
There is no ongoing lymphatic filariasis control program in 2000 in Mali in terms of
preventive chemotherapy treatment or vector control.

To fill these gaps, this current study aims to assess the impact of
albendazole-ivermectin combination treatment on Wuchereria bancrofti infection and
transmission in 6 rural highly endemic villages of Mali.

Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali

Lymphatic Filariasis

Lymphatic filariasis is a public health problem in Mali. The existing data are not up to
date and most of them are more than 15 years old. To address this issue in April 2000,
the investigators started studies to update the epidemiology of lymphatic filariasis. As
a result, in two rural areas (Banambani and Sirakoro) located at about 25 km North-East
Bamako, the parasite prevalence using ICT cards in August 2000 were 16% (n=150) and 15.0%
(n=113) respectively in Banambani and Sirakoro. There is no ongoing lymphatic filariasis
control program in 2000 in Mali in terms of preventive chemotherapy treatment or vector
control.

To fill these gaps, this current study aims to assess the impact of
albendazole-ivermectin combination treatment on Wuchereria bancrofti infection and
transmission in 6 rural highly endemic villages of Mali.

The study will be conducted in three phases: the pre treatment assessment of lymphatic
filariasis infection and transmission parameters, treatment phase with annual single dose
of albendazole and ivermectin and the post treatment assessment of Anopheles gambiae s.l
mosquitoes, the transmission parameters of the vectors in the community, human infection
prevalence post treatment using Giemsa -stained thick smears and others test like the
Immuno chromatographic test (ICT).

''albendazole'' and ''ivermectin''

Impact of Albendazole -Ivermectin Combination Treatment on Wuchereria Bancrofti Infection and Transmission in Mali

vectors are collected with human landing catch technique and the presence of Wb larvae
stage s assessed using dissection method

after the administration of the drug the investigators assess the reaction to the
treatment

night thick smears on eligible volunteers 5 years and above

Before and after design with all eligible volunteers receiving the study drugs.
Administration of a yearly unique dose of albendazole 400mg and ivermectin 150ug/kg
weight ( according to the height).

Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?