Prevention of Levodopa-induced Dyskinesias by Transcranial Static Magnetic Field Stimulation (tSMS)
Sponsored by Fundación de investigación HM
About this trial
Last updated 7 years ago
Study ID
MJFOX-9205
Status
Completed
Type
Interventional
Phase
Phase 2
Placebo
No
Accepting
18 to 80 Years
All
Not accepting
Healthy Volunteers
Trial Timing
Ended 7 years ago
What is this trial about?
This is a randomized sham-controlled double-blind study to test the hypothesis that
transcranial static magnetic field stimulation (tSMS) of the motor cortex improves
levodopa-induced dyskinesias in patients with Parkinson's disease. Half of the patients
will receive real tSMS treatment, the other half will receive sham treatment (placebo).
What are the participation requirements?
Inclusion Criteria
- advanced idiopathic Parkinson's disease (Brain Bank criteria)
- optimal clinical response to dopaminergic medication (>30% UPDRS-III improvement)
- presence of clinically relevant levodopa-induced peak-dose dyskinesias in at least one upper limb
Exclusion Criteria
- MRI-incompatible metal objects in the body (e.g. cardiac pacemakers)
- other main neuropsychiatric co-morbidity