Once-daily Oral Seviteronel in Patients With Castration-Resistant Prostate Cancer Progressing on Enzalutamide or Abiraterone.

1. Subjects must be ≥18 years of age.

2. Subjects or their legal representatives must be able to provide written informed consent.

3. Subjects must have documented histological or cytological evidence of adenocarcinoma of the prostate.

4. Subjects must have an ECOG Performance Score of 0-1.

5. Subjects must have undergone orchiectomy, or have ongoing LHRH analogue therapy prior to drug initiation. Subjects on LHRH analogues must remain on these agents for the duration of the study.

6. Subjects must have castrate levels of testosterone (≤50 ng/dl [1.7 nmol/L]) and have progressive disease at Screening defined as PSA rise determined by a minimum of 2 rising PSA values ≥1 week between each assessment. The PSA value at the Screening visit must be ≥2ng/mL with or without:

7. Subjects must have received abiraterone and/or enzalutamide. Subject must have received either abiraterone or enzalutamide for ≥12 weeks. Other second generation CYP17 inhibitors/androgen receptor antagonists including but not limited to TAK-700 (orteronel), TOK-001 (galeterone) may have been taken in place of abiraterone and ARN-509 (apalutamide) may have been taken in place of enzalutamide.

8. Subjects must have adequate hematopoietic function as evidenced by:

9. Subjects must have adequate liver function, including all of the following:

10. Subjects must have adequate renal function as evidenced by a serum creatinine of <2.0 mg/dl.

11. Subjects must have potassium (K+) >3.5 mEq/l.

12. Subject and his female partner who is of childbearing potential must use 2 acceptable methods of birth control (one of which must include a condom as a barrier method of contraception) starting a Screening and continuing throughout the study period and for 3 months after final study drug administration • Two acceptable forms of birth control include:

1. Subjects who have completed sipuleucel-T (Provenge ®) treatment within 28 days of study drug initiation.

2. Subjects on 5-alpha reductase inhibitors such as finasteride (PROSCAR®, PROPECIA®), or dutasteride (AVODART®) within 28 days of study drug initiation.

3. Subjects who received any investigational agent ≤28 days of study drug initiation.

4. Subjects who received palliative radiotherapy ≤2 weeks of study drug initiation.

5. Subjects with symptomatic CNS metastases.

6. Subjects with a history of another invasive malignancy ≤3 years of study drug initiation.

7. Subjects with a QTcF interval of >470 msec; if the Screening ECG QTcF interval is >470 msec, it may be repeated, and if repeat <470 msec, the subject may be enrolled.

8. Subject with clinically significant cardiac arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes, second degree or third degree atrioventricular heart block without a permanent pacemaker in place)

9. Subject that started a bone modifying agent (e.g. bisphosphonates, denosumab) ≤ 28 days of study drug initiation (note: ongoing bone modifying agents administered > 28 days are allowed).

10. Subject with any medical condition that could preclude subject participation in the study, pose an undue medical hazard, or which could interfere with study results.

11. Subject with Class III or IV Congestive Heart Failure as defined by the New York Heart Association (NYHA) functional classification system within the previous 6 months.

12. Subject with a history of loss of consciousness or transient ischemic attack ≤ 12 months of study drug initiation.

13. Subject with known active HIV, Hepatitis B, or Hepatitis C infections.

14. Subject with known or suspected hypersensitivity to seviteronel, or any components of the formulation

15. Subject with any other condition which in the opinion of the investigator would preclude participation in the study.