We investigate the impact of taste receptors (sweet, bitter and umami) on human
metabolism. There ist growing evidence, that components of the taste signalling system,
including the taste receptor proteins , have important functions in the regulation of
metabolic parameters in non-gustatory tissues.

SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

Disorder of Glucose Regulation

We apply different sweet, bitter and umami taste compounds in a single dose in the human
intervention. We use substances as for instance glucose, sucrose,saccharin and lactisol
in the sweet part, and substances from cabbage, beer or red endive in the bitter part.
For umami we take glutamate.

Blood samples are collected at baseline and 6 times thereafter up to 3hours, to analyse
the incretins GLP-1(glucagon-like peptide 1) and GIP(gastrointestinal polypeptide) and
other peptide hormones as insulin and PYY(peptide tyrosin trosin) in human beings.

Gastrointestinal mucosa is taken by gastroscopy from the lower duodenum from study
subjects for analysis for the presence or absence of functional taste receptors in
gastrointestinal tissues.

sweet block

bitter block

umami-block

gastroscopy

Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

measurement of incretins (GIP, GLP-1) and peptide hormones in human plasma after
consumption of different sugars , sweeteners , bitter tasting ingredients of vegetables
und umami. Measurement of expression levels in human intestinal mucosa before and after
receptor stimulation

Prof. Dr. med.

oral application of sweet tasting substances and antagonists, endoscopic collection of
tissue samples, determination of molecular resonses by qRT-PCR and immunohistochemistry

application of different sugars, artificial sweeteners and sweet-taste antagonists in a
single dose in 300 ml tap water every week up to 7 times and collection of blood samples
over 3 hours

application of purified bitter tasting ingredients of vegetables and hop in 300 ml tap
water , collection of blood samples for 3h (-15,0,15,30,60,120,180 min)

application of glutamate and glutamate +IMP

same procedure as above

gastroscopy with and without oral intervention with artificial sweetener saccharin to
take tissue samples from the upper bowel for the investigation of taste receptor cells in
the upper bowel in human beings

SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

About this trial

Study ID

Status

Type

Phase

Placebo

Accepting

Trial Timing

What is this trial about?

What are the participation requirements?

Locations

Location

Status