Genetic Study of Schizophrenia

- INCLUSION/EXCLUSION CRITERIA:

Inclusion criteria for Siblings (probands and unaffected siblings):

- Probands must have a DSM IV-R diagnosis of schizophrenia,schizoaffective disorder,
psychosis N.O.S. or schizophreniform disorder.

- Probands and Siblings must be between the ages of 18 and 55

- Probands and Siblings must be free of major medical illnesses, but may have
controlled hypertension, thyroid disease, or diabetes.

- Probands and Siblings must have the cognitive ability to consent for themselves.
Those who are judged to have the cognitive ability to consent for themselves at the
time of participation, but do not have the legal capacity to consent for themselves
may participate if the legal guardian /Legal authorized representative (LAR)
provides consent by signing the informed consent form.

- Fluency in English is required.

Exclusion Criteria for Siblings (probands and unaffected siblings):

- Seizure disorder, mental retardation, organic brain damage or other neurological
disease.

- History of any (excepting nicotine-related) DSM5-defined moderate to severe
substance use disorder (or DSM-IV-defined substance dependence).

- Cumulative lifetime history of any (excepting nicotine-related) DSM5-defined mild
substance use disorder (or any DSM-IV-defined substance abuse), either in excess of
5 years total or not in remission for at least 6 months.

- Head trauma with loss of consciousness over 5 minutes from all but genetic sampling.

- Chemotherapy.

- NIMH employees/staff and their immediate family members will be excluded from the
study per NIMH policy

Siblings who do not qualify for the 2-day or 1-day study, may participate in the limited
phenotyping arm in which only a psychiatric interview and a blood draw for genetic
analysis (SCID-DNA) will be performed, case control analysis or be included as part of a
trio (one parent, one sibling, one patient) to study genetic transmission from parents to
offsprings.. All parents are eligible for the study.

Inclusion Criteria. Healthy Volunteers/Controls

To be eligible for this research study, healthy volunteers must be:

- Between the ages of 18 and 55

- Fluency in English is required

Healthy Controls Exclusion Criteria:

They will not be eligible if:

- They have history of DSM IV-R psychiatric diagnosis or severe chronic medical
illness at the time of the study.

- They have a history of any (excepting nicotine-related) DSM5-defined moderate to
severe substance use disorder (or DSM-IV-defined substance dependence).

- They have a cumulative lifetime history of any (excepting nicotine-related)
DSM5-defined mild substance use disorder (or any DSM-IV-defined substance abuse),
either in excess of 5 years total or not in remission for at least 6 months.

- They may not be eligible for the 2-day or 1-day study if they have a first-degree
relative with history of schizophrenia spectrum disorders. However, they may be
included in the SCID_DNA or case control analyses.

- Healthy volunteers must be free of learning disabilities.

- NIMH employees/staff and their immediate family members will be excluded from the
study per NIMH policy.