MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex

- Subject has a diagnosis of Dupuytren's Disease affecting only the metacarpophalangeal joint of the 4th or 5th finger.

- Subject has only one finger affected by the disease.

- Patients will be 35 years of age of older.

- Patients will be able to read, speak, and understand English or have available adequate translation assistance and be able to provide voluntary written consent to participate.

- Female patients who are nursing or pregnant, or plan to become pregnant during the treatment phase.

- Patient has a chronic muscular, neurological or neuromuscular disorder that affects the hands.

- Patient has known allergy to collagenase or any other excipient of Xiaflex.

- Patient has received any collagenase treatments before the first dose of Xiaflex.

- Patient with abnormal coagulation, including patients who have received anticoagulant medications other than low-dose aspirin within 7 days of the injection.