08-44

About this trial

Last updated 11 years ago

Study ID

08-44

Status

Unknown status

Type

Interventional

Phase

Phase 2

Placebo

Accepting

18 to 65 Years

All

Not accepting

Healthy Volunteers

Trial Timing

Started 14 years ago

The purpose of this study is to test whether propranolol is capable of reducing subsequent physiological trauma-related conditioned responses, as well as self-reported post-traumatic stress disorder (PTSD) symptoms.

Inclusion Criteria

- Suffer from chronic PTSD for at least 6 consecutive months;

- Obtain a score of 33 or more on the Impact of Events Scale-Revised:

- For participants aged 40 years: accept to undergo an electrocardiogram assessment. The results of the electrocardiogram must be normal;

- Accept to not commence taking new medications on a regular basis during the study.

Exclusion Criteria

- Hypotension;

- Cardiac rhythm below 55 beats per minute;

- Medical conditions that contraindicates the administration of propranolol;

- Previous adverse reaction to, or non-compliance with, beta-blockers;

- Current use of medication that may involve potentially dangerous interactions with propranolol;

- Any medication that can have an impact on cardiac rhythm;

- Women who are breast feeding;

- Past or present bipolar disorder or psychosis,

- Present substance abuse or dependence, suicidal ideation;

- Participating in psychotherapy other than support psychotherapy;

- An average score above 20 on the Dissociative Experience Scale.

Reducing Reconsolidation of Trauma Memories With Propranolol