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Depression

Effectiveness of Theta-burst Stimulation (TBS) in Patients With Major Depression

Sponsored by University of Regensburg

About this trial

Last updated 13 years ago

Study ID

Uni-Reg-TB1

Status

Completed

Type

Interventional

Phase

N/A

Placebo

No

Accepting

18 to 70 Years
All Sexes

Not accepting

Healthy Volunteers

Trial Timing

Completed — ran Apr 2010 to Oct 2011

What is this trial about?

Repetitive Transcranial Magnetic Stimulation (rTMS) as well as Theta- Burst Stimulation of the frontal cortex are used to modulate the neuronal excitability in patients with depression. In the proposed study we investigate whether high frequent rTMS or Theta-Burst Stimulation of the DLPFC is more effective in patients with a depressive episode.

What are the participation requirements?

Inclusion Criteria

* Episode of depression (unipolar or bipolar)( ICD-10)

* Female or male between 18 and 70 years

* Skills to participate in all study procedures

* 18 or more points in the Hamiliton rating scale or depression

* Stable antidepressant drugs

* Written informed consent

Exclusion Criteria

* Clinically relevant unstable internal or neurological comorbidity

* Evidence of significant brain malformations or neoplasm, head injury

* Cerebral vascular events

* Neurodegenerative disorders affecting the brain or prior brain surgery

* Metal objects in and around body that can not be removed

* Pregnancy

* Alcohol or drug abuse

* Epilepsy or a pathological EEG

* Heart pacemaker

* High dose tranquillizers

Locations

Location

Status