Non-inferiority Study of the Glucosamine Sulfate + Chondroitin Sulfate Association Capsule in Comparison to the CONDROFLEX® Product in Osteoarthrosis of the Knee

Inclusion Criteria

- Individuals must have 55-80 years of age, of both sexes and all races. - Individuals diagnosed with osteoarthritis in the knee with grades 2 to 3 according to the scale of Kellgren / Lawrence [K / L], in conjunction with the measurement of Joint Space Width (JSW), which considers the joint space width, confirmed by radiological examination (s) of the knee (s) affected (s). Grade 1: doubtful narrowing of joint space and possible osteophyte edge Grade 2: defined osteophytes, moderate joint space narrowing Grade 3: moderate multiple osteophytes, definite reduction in joint space, some sclerosis and possible deformity of bone contour Grade 4: large osteophytes, marked joint space narrowing, severe sclerosis and definite deformity of bone contour - Individuals with the capacity to provide a written informed consent, understand and respond to the questionnaires during the study about their disabilities and also with a willingness to adhere to treatment and attend the scheduled appointments for the study. - Persons who have observed the period of wash-out of the drugs listed in question Prohibited Medication

Exclusion Criteria

- Individuals with a history of hypersensitivity to glucosamine sulfate and chondroitin sulfate or any of the components of the formula - Individuals who have used any drug in research within the last 30 days - Individuals with uric acid greater than or equal to 6 mg/dL for women and 7 mg/dL for men or a previous diagnosis of gout and/or on hypouricemic medication - Individuals who are in physical therapy - Individuals with bilateral osteoarthritis, in whom the classification of one of the knees does not fit into grade 2 or 3, according to the scale Kellgren / Lawrence (K/L) together with the measure of Joint Space Width (JSW) - Individuals being treated with glucocorticoid infiltration, or who have injected hyaluronic acid in the joint - Individuals who underwent arthroplasty in any location to be evaluated - Individuals with thyroid dysfunctions that are not controlled (these can only be included in the presence of a normal TSH) - Subjects with decompensated type 2 diabetes mellitus (diagnosed by examination glycated hemoglobin, which should be below 7.5%) - Individuals with infection (known or suspected) in the joints that require therapy with systemic antibiotics - Individuals with significant diseases or clinically significant disorder which, according to the investigator, could interfere with the study or require treatment that might interfere with assessment of efficacy and / or safety - Individuals who have knowledge of being HIV positive or are immunocompromised - Patients who need to use some of the medications listed in item Forbidden Medication - Individuals with other neurological or orthopedic alteration that affects the lower limbs - Individuals with a BMI (Body Mass Index) greater than 27 - Individuals should not initiate physical activity after the inclusion of the study. If they are already doing regular activities before entering the study, the patient may be included as long as he keeps the activities - Individuals with kidney disease.